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This badge points out specific things worth knowing about how a study was designed or run. It is not a rating, and a trial without one isn't free of limitations.

Trial ↕	Condition ↕	Phase ↕	Status ↕	Criteria ↕	N ↕
VeriCel CardioCell therapy for refractory coronary artery disease Sponsored 4 sites · US	Coronary Artery Disease	P3	Recruiting	Adults 45–80 View criteria →	240
18F-AV-1451 PET Imaging in the Preclinical, Prodromal and Dementia Phases of Alzheimer's Disease 0 sites Worth knowing (1)	Alzheimer's Disease	P1	Completed	Adults ≥ 60 View criteria →	—
A Cohort of Outpatients From French Research Memory Centers in Order to Improve Knowledge on Alzheimer's Disease and Related Disorders 29 sites · France	Alzheimer's Disease	Observational	Completed	Adults ≥ 18 View criteria →	—
Adagrasib + pembrolizumab in KRAS G12C-mutated non-small cell lung cancer 4 sites · US + UK Worth knowing (1)	Lung Cancer	P2	Active, not recruiting	Adults ≥ 18 View criteria →	140
Altering Bone Microarchitecture and Mechanics by Off-label Pharmaceutical Intervention 1 site · Canada Worth knowing (1)	Knee Ligament Injury (ACL Tear)	P1	Terminated	Adults 25–45 View criteria →	—
Analgesic Benefits of Genicular Nerve Blocks of the Posterior Knee for Patients Undergoing Anterior Cruciate Ligament (ACL) Reconstruction 1 site · United States Worth knowing (1)	Knee Ligament Injury (ACL Tear)	P4	Terminated	Adults 18–70 View criteria →	—
An Ambispective, Non-interventional, Multiple Cohort Study to Assess the Management of Osimertinib Treatment in Patients With EGFRm Non-small Cell Lung Cancer Under Real-world Conditions in Spain 26 sites · Spain	Lung Cancer	Observational	Recruiting	Adults ≥ 18 View criteria →	500
A Phase 0 Clinical Trial of Microdosing Carboplatin and Molecular Profiling for Chemoresistance 2 sites · United States Worth knowing (1)	Lung Cancer	Early P1	Terminated	Adults ≥ 18 View criteria →	—
A Phase 1, Safety, Tolerability, Single-ascending Dose, Multiple-ascending Dose, Food Effect, and Pharmacokinetic Study of TML-6 in Healthy Volunteers 1 site · United States Worth knowing (1)	Alzheimer's Disease	P1	Completed	Adults 18–80 View criteria →	—
A Pilot Study of Ceftolozane-Tazobactam in Conjunction With Rapid Molecular Diagnosis for Directed Treatment of Pseudomonas Aeruginosa Bacteremia and Pneumonia in Patients With Hematological Malignancies and Hematopoietic Stem Cell Transplantation 1 site · United States Worth knowing (2)	Lung Cancer	P4	Terminated	Adults ≥ 18 View criteria →	—
A Placebo-Controlled, Double-Blind, Parallel-Group, 18-Month Study With an Open-Label Extension Phase to Confirm Safety and Efficacy of BAN2401 in Subjects With Early Alzheimer's Disease 247 sites · United States + Australia + others	Alzheimer's Disease	P3	Active, not recruiting	Adults 50–90 View criteria →	—
A Randomized, Double-Blind, Placebo-Controlled, Single and Multiple Ascending Dose of Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of NH280105 in Healthy Adult Participants 1 site · Australia Worth knowing (1)	Alzheimer's Disease	P1	Completed	Adults ≥ 18 View criteria →	—
A Randomized, Placebo-Controlled, Double-blind, Parallel-Group, Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Orally-administered NGP 555 in Healthy Subjects 1 site · United States Worth knowing (1)	Alzheimer's Disease	P1	Completed	Adults 40–65 View criteria →	—
A Single-center, Patient-blinded, Randomized, 2-year, Parallel-group, Superiority Study to Compare the Efficacy of Augmented ACL Integration Via Platelet-rich-plasma Enriched Collected Autologous Bone Versus Standard ACL Technique 1 site · Switzerland Worth knowing (1)	Knee Ligament Injury (ACL Tear)	N/A	Recruiting	Adults 18–50 View criteria →	107
Association of Endothelial Function With Plaque Vulnerability Assessed by Optical Coherence Tomography in Patients With Acute Coronary Syndrome 1 site · Japan Worth knowing (1)	Coronary Artery Disease	Observational	Completed	Adults 20–90 View criteria →	—
Blood Flow Restriction Training in the Adolescent Patient: Effects on Muscle Strength and Overall Function Following Anterior Cruciate Ligament Reconstruction Surgery 1 site · United States Worth knowing (1)	Knee Ligament Injury (ACL Tear)	N/A	Recruiting	Ages 12–18 View criteria →	120
Bridge-enhanced ACL repair versus reconstruction (BEAR-III) 1 site · US Worth knowing (1)	Knee Ligament Injury (ACL Tear)	P4	Recruiting	Ages 13–35 View criteria →	200
Circuit-specific Neuromodulation for the Treatment of Apathy in Alzheimer's Disease 1 site · United States Worth knowing (2)	Alzheimer's Disease	N/A	Terminated	Adults 50–80 View criteria →	—
Clinical and Radiographic Evaluation of the Efficacy of Laser Versus Silver Diamine Flouride (SDF) in Hall Technique in Primary Teeth 1 site · Egypt Worth knowing (1)	Dental Caries (Tooth Decay)	N/A	Completed	Ages 4–7 View criteria →	—
Clinical Performance of a Bioactive Bulk-Fill Composite in Class II Restorations: A Prospective Split-Mouth Study 1 site · Turkey (Türkiye) Worth knowing (1)	Dental Caries (Tooth Decay)	N/A	Recruiting	Adults 18–50 View criteria →	34
Comparative Evaluation of Vasomotor Function in Saphenous Veins Harvested Using Pedicled vs Conventional Technique 1 site · Canada Worth knowing (1)	Coronary Artery Disease	P1	Completed	Adults 18–80 View criteria →	—
Comparison of Efficacy of Platelet-rich Fibrin, Mineral Trioxide Aggregate and Calcium Hydroxide as Pulpotomy Medicaments in Permanent Teeth With Irreversible Pulpitis 1 site · Pakistan Worth knowing (1)	Dental Caries (Tooth Decay)	P2	Completed	Ages 10–70 View criteria →	—
CT-controlled Advanced Navigation Techniques for Transbronchial Pulmonary Lesion Access; Evaluation of Augmented Fluoroscopy Bronchoscopic Navigation Based Diagnostic Yield 1 site · Netherlands Worth knowing (1)	Lung Cancer	Observational	Completed	Adults ≥ 18 View criteria →	—
Donanemab in early symptomatic Alzheimer's disease (TRAILBLAZER-ALZ 2) 6 sites · US + Sweden + others Worth knowing (2)	Alzheimer's Disease	P3	Completed	Adults 60–85 View criteria →	1,500
Donanemab long-term cognitive outcomes study 6 sites · US	Alzheimer's Disease	P3	Recruiting	Adults 60–85 View criteria →	1,200

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