Phase None NCT05389644

Circuit-specific Neuromodulation for the Treatment of Apathy in Alzheimer's Disease

Massachusetts General Hospital · Interventional, Non-randomized

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Alzheimer's Disease

Study context Single-site study No randomised comparison group

Overview

This proposal will demonstrate that non-invasive brain stimulation is able to modulate cortico-striatal circuits in neurodegenerative patients with apathy, and that doing so results in circuit-specific increases in FC and DA availability. These circuit changes will be accompanied by changes in specific behavioral dimensions of apathy. This work will lead to larger studies which develop personalized, circuit-specific neuromodulation strategies for AD patients suffering from this intractable neuropsychiatric symptom.

Full record on ClinicalTrials.gov (NCT ID NCT05389644).

Recruitment criteria

Age range: 50–80 · Sex: All · Healthy volunteers: Requires diagnosis

Study design

Phase: Phase None
Study type: Interventional
Allocation: Non-randomizedⁱ
Masking: Single-blind
Intervention model: Crossover assignment
Primary purpose: Treatment
Enrollment target: — participants
Started: May 2024

Outcome measures

Locationsⁱ

1 site participated during the trial period. Representative sites shown below; full historical record on ClinicalTrials.gov.

Martinos Center for Biomedical Imaging/Massachusetts General Hospital — Charlestown, Massachusetts (United States)

Sources

REG

ClinicalTrials.gov — NCT05389644

Trial registry · primary record