Research
Novel CRISPR-Cas9 approach achieves durable remission in treatment-resistant B-cell lymphoma
Nature Medicine · 2026
Researchers used CRISPR gene editing to modify patient immune cells, achieving long-term remission in patients who had failed standard chemotherapy. Nine of eighteen patients remained cancer-free at t…
Clinical TrialLecanemab disease-progression effects sustain at 36 months in early-symptomatic Alzheimer's cohort
New England Journal of Medicine · 2026
Across the 36-month observation, the lecanemab arm continued to show a slower decline on CDR-SB than the modelled placebo trajectory derived from the natural-history Alzheimer's Disease Neuroimaging I…
Gut microbiome composition predicts response to checkpoint immunotherapy in metastatic melanoma
Cell · 2026
A study of over 260 melanoma patients found that the mix of bacteria in the gut strongly predicts whether immune checkpoint therapy will work, opening the door to microbiome-based treatments to improv…
Single-cell RNA sequencing reveals heterogeneity in Alzheimer's disease microglia across brain regions
Science · 2026
By analyzing nearly 100,000 individual brain immune cells, scientists identified twelve distinct subtypes of microglia that behave differently in different brain regions, providing new targets for Alz…
GLP-1 receptor agonists reduce cardiovascular event risk independent of weight loss in type 2 diabetes
New England Journal of Medicine · 2026
New analysis of a major diabetes drug trial shows that semaglutide protects the heart through mechanisms beyond just weight loss, suggesting the drug has direct cardiovascular benefits that could appl…
mRNA vaccine platform demonstrates 87% efficacy against H5N1 avian influenza in phase II trial
The Lancet · 2026
Using the same mRNA technology developed for COVID-19 vaccines, researchers achieved 87% protection against bird flu in a clinical trial, with results suggesting the platform could be rapidly adapted …
ComputationalMulti-omics integration identifies three molecular subtypes of non-small-cell lung cancer with divergent immunotherapy response patterns
Nature Cancer · 2026
Three subtypes emerged from unsupervised consensus clustering across the transcriptome / methylome / proteome integrated representation. Subtype A (38% of tumours) — interferon-gamma-rewired, high HL…
Liquid biopsy ctDNA analysis detects pancreatic adenocarcinoma at stage I with 91% sensitivity
Nature Biotechnology · 2026
A blood test that detects fragments of tumor DNA achieved 91% accuracy in identifying early-stage pancreatic cancer, which is notoriously difficult to catch before it spreads and has a five-year survi…
Intermittent fasting alters circadian gene expression in hepatocytes independently of caloric restriction
Cell Metabolism · 2026
Scientists showed that the timing of meals — not just how much is eaten — reprograms metabolic gene activity in liver cells, providing a molecular explanation for why intermittent fasting may have hea…
Review/MetaLong-term outcomes of meniscal-sparing vs meniscectomy approaches in ACL reconstruction: a systematic review with meta-analysis
American Journal of Sports Medicine · 2026
Pooled data from 38 studies (n=11,420) showed that at 10-year follow-up, the meniscal-sparing cohort had a 38% lower incidence of Kellgren-Lawrence grade ≥2 osteoarthritis on the operated knee compare…