Intermittent fasting alters circadian gene expression in hepatocytes independently of caloric restriction

Hatori M, Vollmers C, Zarrinpar A, et al. • Cell Metabolism • PMID SEED007

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✨ AI-Generated Summary

Scientists showed that the timing of meals — not just how much is eaten — reprograms metabolic gene activity in liver cells, providing a molecular explanation for why intermittent fasting may have health benefits separate from weight loss.

⚠ AI summaries are generated automatically and may contain errors. Always refer to the original abstract and full article for clinical or research decisions.

Abstract

Isocaloric comparison of time-restricted feeding versus continuous caloric intake in C57BL/6J mice demonstrated distinct patterns of CLOCK, BMAL1, and CRY1 expression in liver tissue, suggesting that meal timing drives metabolic reprogramming beyond caloric content.

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