mRNA vaccine platform demonstrates 87% efficacy against H5N1 avian influenza in phase II trial
Feldman RA, Fuhr R, Smolenov I, et al. • The Lancet • PMID SEED005
✨ AI-Generated Summary
Using the same mRNA technology developed for COVID-19 vaccines, researchers achieved 87% protection against bird flu in a clinical trial, with results suggesting the platform could be rapidly adapted in the event of a pandemic.
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Abstract
A randomized, double-blind, placebo-controlled phase II trial of an mRNA-based H5N1 influenza vaccine in 400 healthy adults demonstrated 87% vaccine efficacy against laboratory-confirmed H5N1 infection and a favorable safety profile over 12 months of follow-up.