Gut microbiome composition predicts response to checkpoint immunotherapy in metastatic melanoma

Routy B, Gopalakrishnan V, Helmink BA, et al. • Cell • PMID SEED002

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✨ AI-Generated Summary

A study of over 260 melanoma patients found that the mix of bacteria in the gut strongly predicts whether immune checkpoint therapy will work, opening the door to microbiome-based treatments to improve cancer outcomes.

⚠ AI summaries are generated automatically and may contain errors. Always refer to the original abstract and full article for clinical or research decisions.

Abstract

Analysis of pre-treatment stool samples from 263 metastatic melanoma patients receiving anti-PD-1 therapy revealed that high abundance of Faecalibacterium prausnitzii and Bifidobacterium longum correlated with improved overall survival and objective response rates.

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