A Multicenter national prospective cohort study including at least 2300 individuals consecutively recruited from French Research Memory Centers and followed-up over 5 years.
Full record on ClinicalTrials.gov (NCT ID NCT01926249).
A Cohort of Outpatients From French Research Memory Centers in Order to Improve Knowledge on Alzheimer's Disease and Related Disorders
University Hospital, Bordeaux · Observational
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Study context: no flags matched. Amendment history is not available for this trial's data source.
Overview
Results summary
None
Outcome data
| Endpoint | Type | Result | Significance |
|---|---|---|---|
| Progression to clinical dementia stage according to standardized classifications (DSM-IV for dementia and NINCDS-ADRDA for Alzheimer's disease) | Primary | None | None |
| Mortality | Secondary | None | None |
| Loss of autonomy based on functional activity assessment | Secondary | None | None |
| Institutionalisation | Secondary | None | None |
| Speed of cognitive decline based on change in cognitive performances | Secondary | None | None |
| Cardiovascular event (Stroke and Coronary events) | Secondary | None | None |
| Quality of life | Secondary | None | None |
| Prodromal AD (Pre-symptomatic dementia) | Secondary | None | None |
| Longitudinal evolution of biomarkers measured from blood, Cerebro-Spinal Fluid (CSF), structural neuroimaging (MRI) and molecular neuroimaging (18F-FDG PET) | Secondary | None | None |
Full results record on ClinicalTrials.gov.
Study design
- Phase
- Phase None
- Study type
- Observational
- Enrollment (final)
- 2,325 participants
- Started
- December 2011
- Actually completed
- October 2021
Recruitment criteria
Age range: ≥ 18 · Sex: All · Healthy volunteers: Requires diagnosis
Locations
29 sites participated during the trial period. Representative sites shown below; full historical record on ClinicalTrials.gov.
CHU d'Amiens — Amiens (France)
CHU d'Angers — Angers (France)
CHU de Besançon — Besançon (France)
AP-HP - Avicenne — Bobigny (France)
CHU de Bordeaux - Pellegrin — Bordeaux (France)
CHU de Bordeaux - Hôpital Xavier-Arnozan — Bordeaux (France)
CHU de Brest — Brest (France)
CHU de Clermont-Ferrand — Clermont-Ferrand (France)
Hôpitaux civils de Colmar — Colmar (France)
CHU de Dijon — Dijon (France)
CHU de Grenoble — Grenoble (France)
CHU de Lille — Lille (France)
Hospices civils de Lyon — Lyon (France)
AP-HM — Marseille (France)
CHU de Montpellier — Montpellier (France)
CHU de Nancy — Nancy (France)
CHU de Nantes — Nantes (France)
CHU de Nice — Nice (France)
AP-HP - Hôpital BROCA — Paris (France)
AP-HP - Hôpital LARIBOISIERE — Paris (France)
Ap-Hp La Pitié-Salpêtrière — Paris (France)
CHU de Poitiers — Poitiers (France)
CHU de Rouen — Rouen (France)
CHU de Saint-Etienne - Hôpital de la charité — Saint-Etienne (France)
CHU de Saint-Etienne - Hôpital Nord — Saint-Etienne (France)
CHU de Strasbourg — Strasbourg (France)
CHU de Toulouse - Hôpital Purpan — Toulouse (France)
CHU de Toulouse — Toulouse (France)
CHU de Tours — Tours (France)
Sources
ClinicalTrials.gov — NCT01926249
Trial registry · primary record