Association of Endothelial Function With Plaque Vulnerability Assessed by Optical Coherence Tomography in Patients With Acute Coronary Syndrome

Thinning of fibrous cap in atherosclerotic plaques is associated with plaque vulnerability. The high resolution of optical coherence tomography (OCT) provides an accurate measurement of fibrous cap thickness. Endothelial dysfunction is a key component of vulnerable plaque and digital reactive hyperemia-peripheral arterial tonometry (RH-PAT) is a non-invasive automatic and quantitative method to evaluate endothelial function. The investigators will investigate the association between endothelial function assessed by RH-PAT and plaque vulnerability determined by OCT-derived thin-cap fibroatheroma (TCFA).

Full record on ClinicalTrials.gov (NCT ID NCT01578616).

Full results record on ClinicalTrials.gov.

Phase

Phase None

Study type

Observational

Enrollment (final)

100 participants

Actually completed

May 2014

Age range: 20–90 · Sex: All · Healthy volunteers: Requires diagnosis

1 site participated during the trial period. Representative sites shown below; full historical record on ClinicalTrials.gov.